Creating the Mac and Cheese Meatloaf Casserole is simple if you follow these easy steps:

1. Preheat your oven to 350°F (175°C) and lightly grease a baking dish.
2. In a large mixing bowl, combine the ground beef, cooked macaroni, shredded cheddar cheese, breadcrumbs, milk, ketchup, egg, garlic powder, onion powder, salt, black pepper, and smoked paprika. Mix until well combined.
3. Transfer the mixture into the prepared baking dish. Press down gently to form an even layer.
4. Bake the casserole in the preheated oven for 30-35 minutes or until the top is golden brown and the meatloaf is cooked through.
5. Remove from the oven and let it cool for about 5 minutes to help set the structure.
6. Slice and serve warm.

These simple steps will guide you through crafting this delightful casserole that promises to be a hit with your family.